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Is it better to take hydrochlorothiazide in the morning or at night? How to use Hydrochlorothiazide. Take this medication by mouth as directed by your doctor, usually once daily in the morning with or without food. If you take this drug too close to bedtime, you may need to wake up to urinate. It is best to take this medication at least 4 hours before your bedtime.
How long does it take for hydrochlorothiazide to take effect? Pharmacological effects begin in about 2 hours after an oral dose, peaks in 4 hours, and lasts for about 6 to 12 hours. Hydrochlorothiazide is not metabolized, and a majority is excreted in the urine unchanged.
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